The term “immune health” is making a round-about across the globe, especially in the time of unconstrained pandemic breakout.
We have been trying to figure out what could boost our immune system so that we stay strong, healthy, and get enough power to fight the deadly and dangerous disease.
One of the new products that have definitely raised some eyebrows in enhancing the immune system is “CBD oil.”
While we don’t have enough study that links CBD and the immune system vehemently, but the handful of researches on CBD give a hint that we might get control over immune health.
The immune system is a wisdom that comes with risking our lives.
When the early humans lived on trees— the chances of getting killed was 100% if one left its known territory.
Predators like snakes, birds, and other wild animals would prey on us as we also had weak visions.
But evolution is very kind to the species which try to explore the unknown territory— because, with risk, we also unveil the complicated methods of living longer.
Probably that’s the reason why our chaotic ancestors risked their lives, gathered the strength to explore the unknown, and it’s because of them that we have the luxury of retinal vision.
Existentialists and Darwinians believe that nature— by default— tries to kill you every day as its terror will never cease to exist.
But they also believe that “In the wake of terror, we will continue to explore the wisdom to cope-up with terror.”
The immune system is one such valuable “wisdom” that humans have “earned.”
It’s tough to explain why I am calling the immune system a pearl of hard-earned wisdom, but I’d still give it a try:
People living in a closed ecosystem— like natives in Arizona, Sentinels in the Andaman Island, Bunch of local tribes in Amazon— have frail immune systems, and they will die if they are exposed to the new territory.
They have been living there for thousands, perhaps, millions of years, and they never got out of their zones.
They probably couldn’t earn the wisdom to live.
Hence, their immune system is ultra-cold and non-adaptable beyond their demography.
Fortunately, we can travel the world without really worrying about our immune system as our antecedents have done the majority of existential work for us.
Why am I talking about the immune system?
Amid CoronaVirus outbreak— our immune system is tested once again— pretty much like our progenitors.
The question rises— are we immune enough to beat the Corona wrath?
Are we exploring the unknown-deadly virus to find out how we can add another immune wisdom in our arsenal?
The answer is really controversial— some say that let’s expose everyone to the disease so that we can finally say “we have given Corona a going-over,” while most of the people say— let’s sit back home— wait for the right time— stay safe.
Who’s correct? The one who is asking you to explore Corona or the one who is asking you to wait?
I’d leave it for you to answer.
But why is the immune system important?
We can’t ignore the fact that every minute— we are exposed to an endless flurry of viruses, bacteria, infections, and diseases produced by the natural mutilation of the environment.
Our immune system— which is made up of cells, tissues, organs, and of us on the whole— adapts a way that it keeps these invaders at bay.
In fact, our bodies have become so active throughout evolution that it builds antibacterial and antiviral walls against these deadly foreign cells.
You’d like to thank the key players here— White Blood Cells.
White blood cells are further divided into two categories— lymphocytes and phagocytes.
The first category is made up of T-cells and B-cells, which are not suitable hosts to toxic foreign substances as they become hostile over time.
Furthermore, they save the copy of these antigens in their database so that if another invasion occurs— they can remember these invaders and respond quickly.
The second category, i.e., Phagocytes, neutralize these toxic cells and inhibit them from spreading across the body.
They also detect and eliminate the abnormal cells which are not working correctly and request the body to replace new cells.
When the immune system retreats from its essential functions like detecting and eliminating the bad cells— the dead or defective cells accumulate & multiply into a tumor.
The endocannabinoid system— another gift from the evolution
We didn’t have an endocannabinoid system (ECS) in the archaic period.
Maybe— our body has developed this system to achieve something great— something like supporting the immune system.
Well, our recent studies on ECS at least show that it manages the immune functions and plays a vital role in maintaining Homeostasis.
Our body manages the internal-stability despite acute conditions in the outside environment— that’s how it takes on fundamental challenges. This process is called Homeostasis.
Immune cells express both CB1 and CB2 receptors— although the expression levels of CB2 is 10 to 100 times more than that of CB1 in immune cells. 
What’s the point of discussing ECS?
The point is relatively simple— the existence of these receptors in immune cells says something about how we consume CBD products.
Usually, THC directly binds with these receptors in the immune cell that results in euphoric human behavior; however, CBD doesn’t interact with these receptors in the cells directly.
But since Cannabidiol (CBD) is a non-psychoactive component— CBD immune system may have a different working pattern than that of THC.
So, does CBD help the immune system?
Yes, it does in its limit by its method, which is unique from THC. Here’s how it’s suspected to maintain a healthy immune system.
CBD and its interaction with the immune cells.
Generally, our immune cells need a bridge to communicate with an extracellular environment.
Transient receptor potential vanilloid 2 (TRPV2) is a protein that makes this bridge between the immune cells and the extracellular environment.
The more the immune cells interact with the extracellular environment— the more the wisdom it gains to combat diseases and deadly viruses.
Instead of directly binding with the receptors in the cells— CBD activates these proteins and requests another transient receptor potential (TRP) channels to support the immune system.
By doing this— here’s how CBD backs the immune system.
#1 Supports natural killer cells
Our immune system is essential— but to kill the foreign toxics— its over-aggression leads to the death of millions of useful cells.
It’s called the autoimmune condition where our immune system rages a rampant war on all the cells— even the ones which are suitable for our body.
As discussed— T-cells and B-cells are responsible for such mindless acts.
CBD balances out these hyperactive immune cells by suppressing their activities in the autoimmune condition.
For example, if your body is suffering from the inflammatory disease— it’s an excessive response from T-cells and B-cells.
The hyperactive response from them may cause autoimmune disadvantages.
CBD reduces the activities of these cells, thereby preventing you from unbearable inflammation.
Apart from the autoimmune environment— CBD also promotes natural killer cells that respond to bacteria and viruses.
NK or K cells are the innate immune powering cells that reject tumors and virally infected cells.
#2 Manages a healthy inflammatory response
People consider inflammatory responses wrong, which only tells about their ignorance.
The inflammatory response is not the symptom— but the signal from the body that something is not right, and you should get an immediate medical appointment.
It’s a response in which the immune system isolates the infected area and subdues the toxins to spread in other parts of the body.
The immune system secretes cytokines, which are again a large group of proteins.
These proteins relay the information/signals to the immune cells that help in deciding whether to go for an inflammatory response or white blood cell production.
Again— inflammatory responses sometimes go unbearable.
That’s where CBD supplements enter into the picture and suppress the secretion of cytokines.
Research shows that CBD maintains healthy levels of cytokines (TNF and IL-6) and chemokines (MCP-1 and MIP-2).
It means that if the hyper-active Cytokines production affects the body in a negative sense than the positive— then CBD brings down the level of production, thereby leveling the healthy inflammatory response.
The loose definition of healthy inflammation response is nothing but the optimal inflammatory reaction that protects your body just enough to keep the viruses at bay without self-damaging the body.
#3 Controls a healthy gut ecological community
All the systems are made up of ecological communities that are interdependent.
Our large portion of the immune system is expressed in the GI tract, i.e., the gut of the human body.
The gut microbiota has a number of pathogenic microorganisms— regardless of their goodness or badness.
These ecological communities of commensal, symbiotic, and pathogenic microorganisms found in the intestine play pivotal roles in orchestrating balanced immune response from the body.
When excessive inflammation permeates the microbiota community in the gut— our immune system fails to act appropriately.
Even when it acts— it’s partially abnormal or impaired; hence, the intestinal immune response detriments.
One right way to maintain gut microbiota or intestinal immune response is by taking CBD supplements.
Some studies on human trials show that CBD and endocannabinoid systems can maintain the ecological balance in the GI tract, which can reinstate the productive immune response.
That’s why we say “a healthy gut is the road to a healthy life.”
#4 Works as an immunosuppressant
This sounds ironic.
If CBD can act as an immunosuppressant— why do we call it an immune system booster?
Studies have demonstrated that CBD stops T-cells from remembering foreign invaders.
It also modulates (decreases) the production of Chemokine— another protein that belongs to the family of cytokines.
Chemokine senses the presence of viruses and invaders and takes immune cells to the site where they can attack them with the help of white blood cells.
If CBD suppresses T-cells and Chemokine— why is it good anyway? Why should anyone have it when it’s weakening the immune system?
Well, because that’s exactly what we need in autoimmune disease.
When the immune system in the body starts over-analyzing and attacking all the cells— we need immunosuppressants like CBD.
By inhibiting the actions of T-cells and Chemokines— CBD can prevent the operation of over-enthusiastic immune systems in the autoimmune body.
It’s the reason why CBD has also shown great character in organ transplants where the immune system attacks the new guest in the body.
It prevents the immune system from attacking the organ, thereby leading to successful transplantation.
#5 Calms the body and immune system
If you are not calm— you lose a fair chunk of immune power day by day.
The psychological stress and depression decline the immunity— the studies on Lobsters have shown it.
Since lobsters are one of our oldest ancestors— we can safely say that lobsters crumble under stress too.
A defeated-lobster in the battle loses confidence and is thrown away from the territory.
Its stress kills it eventually.
Similarly, our immune system radically goes down with stress.
However, CBD has shown a healthy stress response by directly activating the 5-HT1A serotonin receptors.
The stress-relieving properties that lead to the activation of the “aggressive serotonin hormone” leads to the blood flow in the areas of the brain that results in anxiety and stress.
CBD has been studied on people who feared public speaking.
The research denotes crucial information on how CBD lowers down the stress, rejuvenates, and helps the person stand up straight with his shoulders straight amidst competition.
And when that goes according to the plan— the immune system strengthens.
Stay away from the evangelist calls.
There are CBD evangelists who will try to convince you that it is a one-size-fits-all drug that will attenuate every disease.
We are not one of them.
CBD surely intrigues everyone with the current findings; however, it’s really important that you keep yourself updated with its status in the therapeutic arena.
Based on the data that we have— we assume that CBD best suits the body that has an autoimmune condition, and a healthy body should only resort to it after the medical recommendation.
By the time we discover the vaccines for Corona— let’s see if our body needs more immune power with the help of CBD oil, or are we already good enough to fight it.